At the NHMFL Site in Tallahassee
Ion cyclotron resonance was not included in the original mission
and funding of the NHMFL. However, an NSF funded High-Field Fourier Transform
Ion Cyclotron Resonance Mass Spectrometry Facility designed to develop and
provide state-of-the-art FT-ICR capabilities to external users (university,
government, and industrial labs) nationwide has been established within the
NHMFL. Full details on the scope and administrative structure of that facility
are available on request. Here, we confine our attention to NHMFL's (critical)
role in providing the high-field magnets that will make possible the
highest-performance FT-ICR experiments in the world.
Table of improvement factors (relative to 7 tesla) for FT-ICR performance
parameters
FT-ICR/MS performance parameter 9.4 T 20 T 25 T
Mass resolving power, m/[[Delta]]&m u B0 1.3 2.9 3.6
Upper mass limit u B02 1.8 8.2 12.8
Ion translational energy u B02 1.8 8.2 12.8
Ion radial diffusion rate u 1/B02 0.55 0.12 0.078
Magnetron frequency shift u 1/B0 0.74 0.35 0.28
ICR orbital radius u 1/B0 0.74 0.35 0.28
Coalescence of close-spaced resonances 0.55 0.12 0.078
ICR Magnets with their associated instrumentation are as follows:
- 9.4 tesla magnet, 200 mm diameter horizontal warm bore Oxford magnet (NSF
National High-Field FT-ICR Mass Spectrometry Facility). Scheduled for
operation in May 1995, it will be the highest-field Fourier transform ICR mass
spectrometer in the world, and will be devoted mainly to electrospray of large
biomolecules (e.g., proteins up to 150,000 Dalton or higher), and nucleic acids
(RNA, DNA) to 100,000,000 Da or higher. It will be available to outside users
nationwide and worldwide.
- 7.0 tesla, 150 mm diameter horizontal warm bore Oxford magnet (Marshall
research group). This instrument is designed for the first direct measurement
of optical absorption of mass-selected gas-phase ions and should provide direct
information about ion structure (as shown for neutrals fifty years ago).
- 6.5 tesla, 150 mm diameter horizontal warm bore Oxford magnet (NSF
National High-Field FT-ICR Mass Spectrometry Facility). This magnet is a
platform for development of the 9.4 tesla system. If possible it will be
configured for matrix-assisted laser desorption/ionization (MALDI) and other
laser-based FT-ICR experiments.
- 3.0 tesla, 150 mm diameter horizontal warm bore Extrel/Waters
magnet (Marshall research group). This instrument is the workhorse for general
analytical and chemical applications, including ion-molecule reaction
chemistry, matrix-assisted laser desorption/ionization, and MS/MS. This
instrument is available for collaborative work with outside users.
Access
to the FT-ICR Mass Spectrometry Facility is as follows. No prior approval is
required for members of the initial Co-Investigator Group. Access by
anybody else simply requires a brief (1-2 page) proposal of a given experiment
for review by the Advisory Panel. Large blocks of instrument time will be
partitioned by the Advisory Panel, and short-use periods will be scheduled
locally. For extended user visits (more than a week or two), salary, travel,
and lodging support are available for a limited number of graduate students
selected from non-local user groups. Costs for experiments will be borne
largely by the NSF High-Field FT-ICR Mass Spectrometry Facility grant.
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Curator: Scott Hannahs <sth@magnet.fsu.edu>
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